known as the bible of biomedical engineering, the biomedical engineering handbook, fourth edition, sets the standard against which all other references of this nature are measured. as such, it has served as a major resource for both skilled professionals and novices to biomedical engineering. medical devices and human engineering, the second volume of the handbook, presents material from respected scientists with diverse backgrounds in biomedical sensors, medical instrumentation and devices, human performance engineering, rehabilitation engineering, and clinical engineering. more than three dozen specific topics are examined, including optical sensors, implantable cardiac pacemakers, electrosurgical devices, blood glucose monitoring, human–computer interaction design, orthopedic prosthetics, clinical engineering program indicators, and virtual instruments in health care. the material is presented in a systematic manner and has been updated to reflect the latest applications and research findings.